来自饮食来源的松醇通过synovium中的ceRNA网络调节铁亡:通过功能性食物干预来缓解类风湿关节炎的新策略
Xialin Sun1, Jinlong Liu1, Shijie Wang2
1School of Pharmaceutical Sciences, Jilin Medical University, No. 5, Jilin Street, Fengman District, Jilin City, Jilin Province, 132013, China. 18848101088@163.com.
Food & function
|April 30, 2025
概括
来自胡卜和人参等植物的松醇 (PAL) 通过诱导细胞死亡 (ferroptosis) 和减少炎症来对抗类风湿性关节炎 (RA). 这种饮食化合物对关节健康和治疗慢性炎症疾病有前途.
科学领域:
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 类风湿性关节炎 (RA) 是一种免疫相关的疾病,治疗选择有限.
- 在胡卜和人参中发现的多乙烯Panaxynol (PAL) 显示出潜在的抗炎性质.
- 了解RA中PAL的机制对于开发新的饮食干预措施至关重要.
研究的目的:
- 为了研究帕纳西诺 (PAL) 对抗类风湿性关节炎 (RA) 的作用.
- 阐明PAL诱导铁亡和抗炎作用的机制.
- 为了评估PAL在原诱导关节炎 (CIA) 鼠标模型中的治疗潜力.
主要方法:
- 在体外研究对原诱导性关节炎纤维细胞样同胞细胞 (CIA-FLS),以评估细胞活力,铁亡标志物 (GSH,LPO,铁) 和炎症途径 (NF-κB,细胞因子).
- 在体内实验中使用CIA老鼠模型来评估关节胀,关节炎指数和骨密度.
- 转录组分析和实验验证以确定关键的调节途径 (ceRNA网络,TFR1,NIK).
主要成果:
- 通过诱导铁亡,PAL显著降低了CIA-FLS活力,其特点是改变了GSH,LPO,铁含量和调节表达 (SLC7A11,GPX4).
- PAL抑制了NF-κB通路,降低了促炎性细胞因子分泌 (TNF-α,IL-1β).
- 在体内,PAL治疗缓解了CIA大鼠的关节炎症和改善了骨结构,转录组数据突出显示了铁亡和NF-κB信号调制.
结论:
- 帕纳西诺 (PAL) 通过诱导铁亡和抑制炎症,证明了对类风湿性关节炎 (RA) 的治疗潜力.
- 通过涉及TFR1和NIK轴的ceRNA网络,PAL调节RA的病变发生.
- 帕尔代表了慢性炎症疾病的有希望的饮食干预,支持关节健康的功能性食品开发.
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