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Three-Dimensional Microscopy in Microbiology

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...

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Updated: Jul 6, 2026

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Published on: July 10, 2021

化学信号的高分辨率图案传输来自3D打印的皮科升滴滴网.

Jorin Riexinger¹, Thomas Caganek^1,2, Xingzao Wang¹

¹Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

Advanced materials (Deerfield Beach, Fla.)

|April 30, 2025

概括

研究人员开发了3D打印的picoliter滴滴网络,以精确地控制细菌群体中的基因表达的空间和时间. 这种合成细胞系统可以为生物学和医学中的应用提供图案化信号.

关键词:

通过3D打印打印3D打印.抗微生物剂是一种抗微生物剂.液滴接口二层 (DIBs) 是指液滴接口二层.滴滴网络是一个滴滴网络.基因表达的基因表达方式这是一个纳米孔.图案设计图案设计合成组织合成组织.

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Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

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Last Updated: Jul 6, 2026

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Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

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Published on: June 2, 2022

科学领域:

合成生物学合成生物学
生物技术是生物技术.
化学工程是化学工程的重要组成部分.

背景情况:

合成细胞,如巨大的单状囊泡,可以信号和控制目标细胞.
目前的局限性包括空间/时间分辨率差,无法传输模式信号.

研究的目的:

设计3D打印的picoliter滴滴网络,以精确控制细菌群中的基因表达.
为了实现针对细胞调节的化学信号释放的空间和时间控制.

主要方法:

制造3D打印的皮科升滴滴网络.
利用网络收缩来进行基因表达的空间控制 (分辨率约为50μm).
展示化学信号的存储和受控的时间释放.

主要成果:

从滴滴网络中释放化学信号的模式引导了细菌的基因表达.
实现了高分辨率的基因表达的空间控制.
通过细菌素表达来证明对信号释放和细菌竞争的调节的时间控制.

结论:

3D打印的皮科升滴滴网络为化学信号提供了精确的空间和时间控制.
该系统为基础生物学和医学领域的应用提供了基础,这些应用需要控制化学梯度.
能够在目标细胞群体内对基因表达进行局部控制.