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循环氨基酸与儿童肥胖之间的关联:系统性审查和元分析
Yingli Si1, Tingting Zhang1, Xiangyu Wang1
1Department of Pediatrics,Shandong Provincial Third Hospital,No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City,Shandong Province, China.
Journal of clinical research in pediatric endocrinology
|April 30, 2025
概括
这次审查发现特定的氨基酸水平与儿童肥胖有关. 较高的谷氨酸含量可能会防止肥胖,而分支链氨基酸如氨酸和氨酸与肥胖风险增加有关.
科学领域:
- 营养生物化学 营养生物化学
- 儿科内分泌学 儿科内分泌学
- 代谢健康 代谢健康
背景情况:
- 儿童肥胖是一个日益严重的全球健康问题,其病因复杂.
- 氨基酸在新陈代谢过程中起着至关重要的作用,它们的失调可能会影响体重.
- 了解氨基酸和儿童肥胖之间的关系可以为预防和治疗策略提供信息.
研究的目的:
- 系统地审查和分析有关氨基酸在儿童肥胖中的作用的现有文献.
- 确定与儿童肥胖相关的特定氨基酸.
- 为了澄清氨基酸是否作为儿童肥胖的指标或贡献者.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 在主要的科学数据库 (PubMed,Embase,Web of Science等) 中进行全面的文献搜索. ) 的情况.
- 统计分析包括异质性评估 (I2统计) 和出版偏差评估 (漏斗图表,埃格尔测试).
主要成果:
- 五项涉及1229名参与者的研究符合纳入标准.
- 在氨基酸水平和儿童肥胖之间发现了显著的关联.
- 谷氨酸与肥胖相反相关 (SMD = -0.48),而白氨酸 (SMD = 0.79) 和氨酸 (SMD = 0.67) 与肥胖相反相关. 较高的谷氨酸含量与56%更低的肥胖率相关 (OR = 0.44).
结论:
- 特定的氨基酸,特别是分支链氨基酸 (BCAA),与儿童的BMI和肥胖指标的增加有关.
- 谷氨酸可能具有对儿童肥胖的保护作用.
- 需要进一步的纵向和干预研究来证实这些发现,并探索有针对性的干预措施.
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