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Updated: May 12, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

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CARM1/PRMT4促进了XPF-ERCC1异构体组合,并维持了核酸切除修复活动

Hiroyuki Niida1, Masahiko Ito2, Kenta Iijima3

  • 1Department of Molecular Biology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.

Nucleic acids research
|April 30, 2025
PubMed
概括

氨基甲基转移酶CARM1对于稳定XPF-ERCC1DNA修复复合体至关重要. 丢失CARM1降低了XPF蛋白水平,损害了DNA修复,增加了紫外线敏感性,突出了它在基因组稳定中的作用.

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