长时间太空飞行后几年的动脉结构和功能
Stuart M C Lee1, L Christine Ribeiro1, David S Martin1
1KBR, Houston, Texas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|April 30, 2025
概括
长时间的太空飞行并没有导致宇航员在任务后五年内持续的心血管变化. 研究表明,在太空旅行后,动脉结构或功能没有显著差异,这表明宇航员的心血管健康良好.
科学领域:
- 心血管生理学心血管生理学
- 太空医学 太空医学
- 宇航员健康 宇航员健康
背景情况:
- 太空飞行带来氧化应激和炎症的风险,可能加速心血管疾病.
- 了解太空任务对心血管的长期影响对于宇航员健康至关重要.
- 以前的研究集中在飞行后立即的心血管状况上.
研究的目的:
- 为了确定长期太空飞行 (>4个月) 是否在着陆后的几年内诱导心血管和手臂动脉的结构和功能变化.
- 评估宇航员在国际空间站 (ISS) 任务后的长期心血管健康状况.
主要方法:
- 在13名国际空间站宇航员飞行前和飞行后5年内测量了常见动脉 (CCA) 内心介质厚度 (cIMT),延伸能力和硬度.
- 评估手臂动脉在飞行前和飞行后的内皮依赖和独立的血管扩张.
- 从NASA档案中检查了宇航员心血管参数的健康记录.
主要成果:
- 与降落后5年之前的飞行前测量相比,在飞行后cIMT,CCA刚性,延展性或臂动脉血管扩张方面没有发现显著差异.
- 在研究的宇航员队伍中,在飞行后的5年内没有记录新诊断的心血管疾病.
- 氧化应激和炎症的生物标志物显示着陆后的动态变化,但可能不反映长期健康后果.
结论:
- 在国际空间站长期太空飞行并没有导致在飞行后5年内阴道和手臂动脉的不利结构或功能变化.
- 在太空任务后的几年里,宇航员没有表现出动脉壁厚度,硬度或内皮功能障碍的增加.
- 持续的长期监测对于评估终身心血管风险至关重要,特别是在未来的深空任务中.
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