针对复杂尾炎进行 laparoscopic 尾切除术的儿童的三重或双重抗生素治疗:一个病例对照研究
Kai-Zheong Lim1,2, Ramesh M Nataraja1,2,3, Maurizio Pacilli1,2,3
1Department of Paediatric Surgery, Monash Children's Hospital, Clayton, Victoria, Australia.
与传统的三重抗生素 (TA) 治疗方案相比,针对儿科复杂尾炎 (CA) 的双重抗生素治疗方案 (DA) 改善了康复时间,降低了成本. 在DA治疗方案中,没有增加术后并发症,如腹内.
科学领域:
- 儿科手术 儿科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 从历史上看,三重抗生素 (TA) 治疗方案是儿科复杂尾炎 (CA) 的标准.
- 2018年11月,该机构转向双抗生素 (DA) 治疗方案.
研究的目的:
- 为了比较TA与DA疗法治疗的CA儿童的术后结果.
- 评估DA治疗方案在腹腔镜尾切除术 (LA) 中的疗效和安全性.
主要方法:
- 对197名儿童进行CA的LA进行临床和实验室数据的回顾性分析 (2017年11月至2019年).
- 99名接受TA治疗的患者和98名接受DA治疗的患者之间的比较.
- 使用费舍尔精确测试和曼-惠特尼U测试进行统计分析 (p < 0.05显著).
主要成果:
- 在TA和DA组之间,腹内 (IAA) 或手术部位感染没有显著差异.
- DA组显示出明显更快的脱光时间 (48比72小时,p=0.003).
- DA组的住院时间较短 (p=0.04) 和药物成本显著降低 (p<0.0001).
结论:
- 在儿童CA患者中,DA疗程提供了改善的术后温度控制和更快的恢复.
- DA疗法是TA的安全和经济有效的替代方案,而不会增加并发症率.
- 在复杂尾炎的腹腔镜尾切除术后,DA疗法促进了更快的整体康复.
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