肠道微生物群 Lactobacillus johnsonii通过调节肠道尿酸和肠道微生物群衍生的丁酸盐来缓解高尿血
Rongshuang Han1, Zan Wang1, Yukun Li1
1Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China.
Chinese medical journal
|April 30, 2025
概括
肠道细菌,特别是Lactobacillus johnsonii,可以通过减少UA的产生和增加其分泌来降低尿酸 (UA) 在高尿血 (HUA) 的水平. 这突出了肠道微生物群.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在尿酸 (UA) 代谢中起着至关重要的作用,但它们调节高尿血症 (HUA) 中肠道UA代谢的确切机制尚未完全理解.
- 研究肠道在HUA中的作用对于了解疾病的发病过程至关重要.
研究的目的:
- 为了探索高尿血症 (HUA) 中肠道的功能.
- 阐明肠道微生物群调节肠道尿酸 (UA) 代谢的机制.
主要方法:
- 建立了超尿血症 (HUA) 的小鼠模型.
- 利用了通过抗生素消耗肠道微生物群的方法.
- 使用16SRNA基因测序分析了肠道微生物组成.
- 进行了代谢学分析,以确定微生物组衍生代谢物.
- 进行了体内和体外实验以阐明机制.
主要成果:
- 抗生素治疗增加了血清UA,破坏了纯素代谢,并减少了Lactobacillus的丰富性.
- 超尿血症 (HUA) 的小鼠表现出较低的Lactobacillus johnsonii (L. johnsonii) 含量和减少的肠道丁酸盐.
- 补充L. johnsonii通过抑制UA合成和促进 purin代谢物分泌,显著降低了血清UA.
- L. johnsonii通过上调尿酸载体ABCG2 (腺三酸盐结合盒载体,亚族G,成员2) 的表达来增强肠道UA分泌.
- 酸盐水平被L. johnsonii增加,后者通过Wnt5a/b/β-catenin信号通路对ABCG2表达进行了上调.
结论:
- 肠道微生物群及其代谢物直接影响肠道尿酸 (UA) 代谢.
- 准肠道微生物群及其代谢物是一种有前途的治疗策略,用于饮食引起的高尿血症 (HUA).
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