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Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
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The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms never become fossils. Moreover, the fossil record only exhibits fossils that have been discovered. Nevertheless, sedimentary rock fossils of long-lived, abundant, hard-bodied organisms dominate the fossil record. These fossils offer valuable information, such as an organism's physical form, behavior, and age. Studying the fossil record helps...
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生态循环数据库 (2025年)

Peter D Karp1, Suzanne Paley1, Ron Caspi1

  • 1Bioinformatics Research Group, SRI International, Menlo Park, California, USA.

EcoSal Plus
|April 30, 2025
PubMed
概括
此摘要是机器生成的。

EcoCyc是一个全面的生物信息数据库,详细介绍了大肠杆菌K-12 MG1655基因组和细胞功能. 它提供了广泛的数据和工具,用于系统级理解和分析大肠杆菌生物学.

关键词:
埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.生物信息学是一种生物信息学.我们的数据库数据库数据库数据库.

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科学领域:

  • 微生物学 微生物学
  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学

背景情况:

  • EcoCyc是一个生物信息学数据库,详细介绍了大肠杆菌Escherichia coli K-12 MG1655.5的基因组和生物化学机制.
  • 它是大肠杆菌生物学家和与相关微生物工作的研究人员的电子参考.

研究的目的:

  • 描述大肠杆菌细胞的完整分子目录及其分子部分的功能.
  • 为了促进系统层面对大肠杆菌的理解.
  • 为分析高通量数据集提供工具.

主要方法:

  • 整理和整合有关大肠杆菌基因,产品,代谢物,反应,操作和通路的数据.
  • 包括关于基因表达调节,本质性和生长条件的信息.
  • 开发和使用稳定状态代谢流量模型和全细胞模型.

主要成果:

  • 该数据库包含有关大肠杆菌基因产物,代谢物,反应,操作子和代谢途径的详细信息页面.
  • 包括关于基因调节,基本性和生长营养需求的数据.
  • 代谢流量模型预测了各种条件和基因淘汰的流量率,营养吸收和生长率.

结论:

  • 生态循环为大肠杆菌研究提供了有价值的综合资源.
  • 数据库和相关模型有助于系统级分析和预测细胞行为.
  • 它支持各种各样的研究应用,从基础生物学到代谢工程.