Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients.

Gynecologic oncology·2015
Same author

A new 5' terminal murine GAPDH exon identified using 5'RACE LaNe.

Molecular biotechnology·2005
Same journal

Serum GRP78 as a potential biomarker for early liver injury and active fibrogenesis in alcohol-associated liver disease.

Clinical and experimental medicine·2026
Same journal

Beyond polarization: a receptor-centered framework for macrophage function and therapy in skin diseases.

Clinical and experimental medicine·2026
Same journal

UBA2: the gatekeeper of the sumoylation pathway and its multifaceted roles in human diseases and therapeutic prospects.

Clinical and experimental medicine·2026
Same journal

Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics.

Clinical and experimental medicine·2026
Same journal

Identifying coagulation-related biomarkers in steroid-induced osteonecrosis of the femoral head: implications for early diagnosis and treatment.

Clinical and experimental medicine·2026
Same journal

KIF7 promotes the proliferation of clear cell renal cell carcinoma by activating the WNT/β-catenin signaling pathway.

Clinical and experimental medicine·2026
查看所有相关文章

相关实验视频

Updated: Jun 19, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.6K

多发性硬化症的统一模型

Daniel Jonathan Park1,2

  • 1Melbourne Bioinformatics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Australia. djp@unimelb.edu.au.

Clinical and experimental medicine
|April 30, 2025
PubMed
概括
此摘要是机器生成的。

这项研究提出了多发性硬化症 (MS) 的新模型,其中爱斯坦-巴尔病毒 (EBV) 的重新激活先于人类疹病毒6A (HHV-6A) 的重新激活,这可能解释MS的发病因子,并指导未来的治疗方法.

关键词:
自动抗体是一种自身抗体.细胞毒性 细胞毒性疾病模型的疾病模型.这是EBV的EBV.这就是HHV-6A.多发性硬化症是多发性硬化症.进步的MSMS是什么意思在RRMS中使用RRMS.病毒的重新激活.

更多相关视频

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.3K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.2K

相关实验视频

Last Updated: Jun 19, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.6K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.3K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.2K

科学领域:

  • 神经免疫学 神经免疫学
  • 病毒病原体的产生
  • 神经退行性疾病 神经退行性疾病

背景情况:

  • 多发性硬化症 (MS) 是一种复杂的神经退行性疾病,原因不明.
  • 目前的模型往往侧重于自身免疫,但面临挑战.
  • 之前的假设表明病毒再激活在MS中起作用.

研究的目的:

  • 为多发性硬化症提出一种替代性病毒再激活中继模型.
  • 为了解释MS病变发生过程中的病毒反应的序列.
  • 为了解多发性硬化和开发疗法提供一个新的框架.

主要方法:

  • 该研究提出了一个基于现有证据的理论模型.
  • 它整合了病毒学,免疫学和神经学的发现.
  • 没有产生新的实验数据;这是一个概念模型.

主要成果:

  • 拟议的模型假定,在大脑中的爱斯坦-巴尔病毒 (EBV) 反激活之前,人类疹病毒6A (HHV-6A) 在寡细胞和神经元中的反激活.
  • 这一序列可能导致复发性缓解性多发性硬化症 (RRMS),其特征是病毒爆发,CD8+ T细胞反应和炎症.
  • 可能会出现自我向抗体,这可能标志着一些患者的渐进性多发性硬化症的开始.

结论:

  • 这个新模型协调了与MS相关的各种证据.
  • 它表明MS中病毒重新激活事件的特定顺序.
  • 该模型为未来的MS研究和治疗策略提供了可测试的假设和方向.