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Updated: May 8, 2025

Budding Yeast Protein Extraction and Purification for the Study of Function, Interactions, and Post-translational Modifications
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Published on: October 30, 2013

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通过SUMOylation在芽酵母中调节错误折叠的蛋白质聚合和降解

Austin Folger1, Emily Gutierrez-Morton1, Marie-Helene Kabbaj1

  • 1Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300.

Molecular biology of the cell
|April 30, 2025
PubMed
概括

SUMOylation,即小型泛胺类修饰剂 (SUMOs) 的附着,通过蛋白酶体促进错误折叠的亨廷丁蛋白 (Htt) 的降解. 这一过程有助于保持蛋白质的溶解性,并防止与神经退行性疾病相关的聚合.

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