非对称的四牙混合素结合-气结合宏循环,用于在水有机介质中的阴离子识别
Somjutar Opascharoenboon1, Sutthipoj Vigromsitdet1, Norraset Cheevathanomsak1
1Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Rd, Thung Phayathai, Ratchathewi, Bangkok, 10400, Thailand.
具有素结合和素结合捐赠体的新合成宏循环显示了增强的离子识别. 这些非对称的受体提供了更好的选择性和结合亲和力,即使在水性环境中.
科学领域:
- 超分子化学 超分子化学
- 阳离子的识别方法
- 有机合成 有机合成
背景情况:
- 阳离子在生物,环境和工业系统中起着至关重要的作用.
- 设计用于选择性离子检测的合成受体是具有挑战性的,因为离子的特性如高水能和pH依赖性.
- 受体需要具有多个非共价相互作用的预先组织的结合点来稳定阴离子结合.
研究的目的:
- 合成和评估用于离子识别的新型电荷中性四牙酸宏循环.
- 为了研究非对称的素结合 (XB) 和结合 (HB) 供体组合对阴离子结合亲和力和选择性的影响.
- 将这些宏循环的性能与对称的类似物和非循环前体进行比较.
主要方法:
- 阶段性铜(I) 催化亚酸循环添加 (CuAAC) 宏循环化合成.
- 在溶液中进行阳离子结合研究,以确定亲和性和选择性.
- 密度函数理论 (DFT) 计算以阐明绑定模式和相互作用.
主要成果:
- 与对称的HB类似物相比,非对称的XB/HB宏循环表现出增加的离子结合亲和力和改变的选择性.
- 这些宏观循环在水的存在下保持了结合能力.
- 宏环效应显著增强非对称的XB/HB宏环中的化物结合,而不是它们的非循环对应物.
- DFT研究揭示了一种结合模式,涉及部位的双σ孔相互作用和键相互作用.
结论:
- 包含XB和HB捐赠体的非对称宏循环为增强的离子识别提供了一个有希望的策略.
- 在预先组织的宏循环框架内,不同非共价相互作用的结合提高了受体的性能.
- 这些发现有助于开发先进的传感器和离子分离材料.
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