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基于细胞的小分子查 识别蛋白质稳定调节剂 增强因子VIII Missense 突变分泌物

Vishal Srivastava1, Zhigang Liu1, Wei Wei1

  • 1Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA.

Biomolecules
|April 30, 2025
PubMed
概括

苏贝罗伊兰尼利德酸 (SAHA) 在血友病A模型中增强了凝血因子VIII (FVIII) 的分泌和活性. 这种蛋白质稳定调节剂为FVIII误解突变提供了一个有前途的治疗策略.

关键词:
BiP/GRP78的使用情况这就是Vorinostat.第八个因子的因素.蛋白质稳定调节剂 蛋白质稳定调节剂这是一种分泌的分泌物.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.