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Updated: May 15, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
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在SARS-CoV-2变体进化过程中,RBD/hACE2接口的微妙变化:分子动力学研究

Aria Gheeraert1,2, Vincent Leroux3, Dominique Mias-Lucquin3

  • 1Laboratory of Mathematics (LAMA), CNRS, University of Savoie Mont Blanc, 73370 Le Bourget-du-Lac, France.

Biomolecules
|April 30, 2025
PubMed
概括

由于关键突变,Omicron变异体表现出与Delta相比,对人类ACE2的结合稳定性更强,这是由关键突变推动的. 这项分子动力学研究解释了Omicron通过高级尖端受体结合域相互作用对Delta的持久性.

关键词:
在 RBD-hACE2 绑定中使用 RBD.这就是SARS-CoV-2病毒.分子动力学模拟,分子动力学模拟每个残留物的相互作用.变种演变的变种演变.

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