胸前大动脉动脉瘤,解剖和双侧大动脉损伤中的表观遗传生物标志物:综合性审查
Dimitrios E Magouliotis1, Serge Sicouri1, Noah Sicouri2
1Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA.
Biomolecules
|April 30, 2025
概括
像DNA甲基化和miRNA调节这样的表观遗传机制是胸前大动脉疾病 (TAD) 的关键驱动因素. 针对这些可逆变化的治疗为TAD提供了有前途的治疗和诊断策略.
科学领域:
- 心血管生物学 心血管生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 翻译医学是一种翻译医学.
背景情况:
- 胸前大动脉疾病 (TAD) 包括危及生命的疾病,如胸前大动脉动脉瘤 (TAA) 和急性A型大动脉解剖 (ATAAD).
- 虽然遗传学是已知的贡献者,但表观遗传机制越来越被认为是TAD病变发生的关键调节者.
- 了解这些表观遗传因素对于开发新的治疗和诊断方法至关重要.
研究的目的:
- 综合审查表观遗传修饰在TAD病变发生中的作用.
- 探索DNA甲基化,基因组修饰和微RNA (miRNA) 调节在血管重塑,细胞外矩阵降解和内皮功能障碍中.
- 突出表观遗传生物标志物和TAD管理的治疗方法的转化潜力.
主要方法:
- 对胸前大动脉疾病中的表观遗传机制现有文献的综述.
- 对研究TAA和ATAAD中DNA甲基化,基因素修饰和miRNA失调的研究进行分析.
- 对表观遗传调节疗法的临床前数据的检查.
主要成果:
- 异常的DNA甲基化会影响TAA和ATAAD中与血管完整性和炎症相关的基因.
- 基斯修改影响光滑肌肉细胞表型切换,影响动脉瘤的进展.
- 失调的miRNA表达有助于内皮功能障碍和细胞外矩阵重塑,表明生物标志物的潜力.
结论:
- 表观遗传修饰在TAD病变发生过程中至关重要,由于其可逆性,它们提供了有前途的治疗标.
- 表观遗传生物标志物在TAD中具有早期检测,风险分层和精密医学的翻译潜力.
- 需要进一步的研究来将表观遗传发现纳入临床实践,以改善TAD管理.
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