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静脉和痴呆症发生之间的关联:全国性基于人口的队列研究
Ho Geol Woo1, Ju-Young Park2, Moo-Seok Park3
1Department of Neurology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
PloS one
|April 30, 2025
概括
静脉 (VV) 可能会增加痴呆风险,但治疗VV似乎会降低血管痴呆 (VD) 的风险. 这项大型研究强调了循环健康和认知衰退之间的潜在联系.
科学领域:
- 神经学和血管医学 神经学和血管医学
- 流行病学和公共卫生研究研究 流行病学和公共卫生研究
背景情况:
- 静脉 (VV) 和痴呆症是普遍存在的疾病,对它们之间的联系的研究有限.
- 了解VV和痴呆症之间的联系对于公共卫生战略至关重要.
研究的目的:
- 调查静脉 (VV) 存在与痴呆症发展之间的关系.
- 评估VV的治疗是否与一般人口队列中痴呆症的发生相关.
主要方法:
- 对430875名韩国参与者的长度研究 (2005-2010).
- 由ICD-10代码定义的静脉 (VV);由ICD-10代码定义的痴呆症 (所有原因,阿尔茨海默氏症,血管).
- 倾向性得分匹配用于比较VV存在和治疗组.
主要成果:
- 存在VV与所有原因痴呆的风险增加有关 (HR: 1.235,95% CI: 1.147-1.329).
- 治疗VV与血管痴呆症 (VD) 的风险降低显著相关 (HR:0.566,95%CI:0.382-0.841).
- 在VV存在/治疗和阿尔茨海默病风险之间没有发现显著的关联.
结论:
- 静脉静脉 (VV) 的存在可能与患痴呆症的风险更高有关.
- 治疗静脉 (VV) 显示出降低血管痴呆症 (VD) 发病率风险的潜力.
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