在肯尼亚西部结核病感染者中自我报告的COVID-19严重程度,2021年
Hellen C Barsosio1,2, Brian Tangara1, Joshua Ongalo1
1Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
PLOS global public health
|April 30, 2025
概括
结核病感染 (TBI) 在肯尼亚队列中没有增加严重COVID-19的风险. 高龄,而不是TBI或HIV,与严重的COVID-19结局有关. 这一发现在全球范围内是一致的.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 结核病感染 (TBI) 在全球范围内非常普遍,特别是在资源较低的环境中.
- 创伤损伤对COVID-19严重性的影响,特别是与HIV同时存在的影响,仍然不清楚.
- 了解这些相互作用对于管理结核病流行地区的公共卫生至关重要.
研究的目的:
- 调查TBI和严重的COVID-19之间的联系.
- 探索艾滋病毒共同感染在这种关系中的作用.
- 在结核病流行地区识别严重COVID-19的风险因素.
主要方法:
- 肯尼亚西部的一项队列研究跟踪了有症状和无症状的COVID-19患者 (8-80岁).
- 通过PCR证实了SARS-CoV-2;使用QuantiFERON-TB Gold Plus诊断了TBI.
- 在14天内使用inFLUenza-Patient-Reported-Outcome Plus工具评估疾病进展情况.
主要成果:
- 在33.2%的参与者中存在TBI;11.1%感染了艾滋病毒.
- 严重的COVID-19与TBI没有显著相关 (OR 1.73,p=0.21).
- 年龄较大 (≥50岁) 与严重的COVID-19显著相关 (OR 3.73,p=0.004).
- 在调整后,艾滋病毒与严重的COVID-19没有显著相关 (aOR2.77,p=0.070).
结论:
- 创伤并不是严重COVID-19的显著风险因素.
- 老年是严重COVID-19的关键决定因素,与全球观察一致.
- 这些发现强调了年龄在COVID-19风险分层中的重要性,无论结核病状况如何.
相关概念视频
01:26Pulmonary Tuberculosis IV
116
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
116
01:29Pulmonary Tuberculosis I
198
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
198
01:31Pulmonary Tuberculosis III
257
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
257
01:28Pulmonary Tuberculosis V
145
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
145
01:28Pulmonary Tuberculosis II
188
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
188