相关实验视频

Updated: Jun 11, 2026

Cryosectioning Method for Microdissection of Murine Colonic Mucosa

Cryosectioning Method for Microdissection of Murine Colonic Mucosa

Published on: July 12, 2015

一种适用于胃肠道的透鼻内镜的薄型冷活检装置,兼容透鼻内镜

David O Otuya^1,2, Hamid Farrokhi¹, Yogesh Verma^1,2,3,4

¹Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.

Science translational medicine

|April 30, 2025

概括

一种新型的超小型冷活检装置 (μCryoProbe) 提供高质量,定向良好的胃肠组织样本. 这项技术可以使用小型内镜进行无化手术,改善患者的诊断并降低风险.

科学领域:

胃肠病学胃肠病学
医疗器械医疗器械
生物检查技术生物检查技术

背景情况:

传统的内镜活检采用子,通常需要镇静,并产生低于最佳的样本.
限制包括粉碎工件,组织定向差,以及深度控制问题.
较小的内镜用于无化手术,其工作道较小,限制了活检工具的尺寸.

研究的目的:

开发和评估一个图像导向,深度控制,超小直径 (1.2毫米) 低温活检装置 (μCryoProbe).
为了评估通过μCryoProbe获得的活检的质量和尺寸,与传统的子相比.
探索μCryoProbe在未经镇静的内镜手术中的潜力.

主要方法:

优化了冷却液流量,以提高组织结和控制结深度.
在ex vivo临床前组织中测试了μCryoProbe,在体内猪模型中测试,并镇静了人类参与者.
将冷藏活检与从食道,胃和十二指肠的取活检进行了比较.

主要成果:

CryoProbe始终产生高质量的粘膜冷活检.
活检显示了最佳的组织方向,没有粉碎的文物.
在人类参与者中证明了成功的胃肠道活检采集.

结论:

CryoProbe与子相比,产生更优质的活检质量.
这种超小的设备可以更轻松地使用较小的内镜,从而可能减少镇静需求.
改善活检质量可以提高患者的诊断和程序可行性.

更多相关视频

Subcellular Fractionation from Fresh and Frozen Gastrointestinal Specimens

Subcellular Fractionation from Fresh and Frozen Gastrointestinal Specimens

Published on: July 15, 2018

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Published on: July 19, 2024

相关概念视频

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due to...

Endoscopic Procedures III: Video Capsule Endoscopy

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...