瘤外科手术后的术内定向流体疗法和结果:系统性审查和元分析
Zhaosheng Jin1, Alina Razak1, Huang Huang2
1From the Department of Anesthesiology, Stony Brook University Medicine Center, Stony Brook, New York.
Anesthesia and analgesia
|April 30, 2025
概括
在瘤外科手术中,定向流体治疗 (GDFT) 显著缩短住院时间,减少并发症. 这种方法还可以加速肠道功能恢复,改善癌症手术后患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 麻醉学 麻醉学
- 关键护理医学 关键护理医学
背景情况:
- 固体器官恶性瘤的大型手术需要谨慎的流体管理.
- 不适当的液体管理可能会对癌症患者的康复和结果产生负面影响.
- 优化术后护理对于随后的瘤治疗计划至关重要.
研究的目的:
- 系统地审查和元分析目标导向流体疗法 (GDFT) 对瘤外科手术术后期结果的影响.
- 将GDFT与接受重大外科手术的癌症患者的常规临床护理进行比较.
主要方法:
- 在PubMed,EMBASE,CINAHL和Web of Science的系统文献搜索.
- 包括24个随机对照试验 (RCT),其中GDFT手臂有1172名患者,常规护理手臂有1186名患者.
- 主要结局:住院时间和术后并发症发生率. 二次结果:器官特异性并发症和肠道功能恢复.
主要成果:
- GDFT显著减少了住院时间 (MD,1.57天;P <.01).
- GDFT降低了手术后并发症的发生率 (RR,0.74;P = .03).
- 使用GDFT,肠功能恢复速度更快 (MD,0.58天;P = .01).
结论:
- 在瘤外科手术中的手术内GDFT与减少住院和并发症率有关.
- 在癌症手术患者中,GDFT有助于更快地恢复肠道功能.
- 需要进行进一步的研究,以确定改善的早期结果是否会转化为更好的长期瘤结果.
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