在COVID-19疫苗接种后的嗅觉障碍
M Kawabata1, E Mori1, N Yanagi1
1Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan.
Rhinology
|April 30, 2025
概括
在COVID-19疫苗接种后,已经报告了诸如厌氧和氧等嗅觉障碍. 需要进一步的研究来确认因果关系,并了解这些疫苗接种后感官变化背后的机制.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍是COVID-19的一个已知的症状.
- 疫苗接种后的不良事件受到密切监测.
- COVID-19疫苗接种和嗅觉障碍之间的关系需要进行调查.
研究的目的:
- 系统地审查COVID-19疫苗接种后报告的嗅觉障碍病例.
- 描述这些病例的临床表现,诊断结果和管理.
- 探索潜在的机制和进一步研究的需要.
主要方法:
- 对16个报告的病例进行系统审查.
- 分析患者人口统计,疫苗类型,症状发作,持续时间和严重程度.
- 使用嗅探棒测试和T&T嗅觉测试进行诊断评估.
- 对治疗方法和假设的病理生理机制的审查.
主要成果:
- 在接种疫苗后一周内报告了16例嗅觉障碍 (厌氧,氧,低氧) 病例.
- 大多数患者接受了mRNA (Pfizer,Moderna) 或病毒载体 (AstraZeneca) 疫苗.
- 症状持续数周到数月;诊断通常表明轻度低血.
- 治疗包括维生素,嗅觉训练和皮质类固醇;假设对尖端蛋白的炎症反应.
结论:
- 在COVID-19疫苗接种后可能出现嗅觉障碍,但没有确立直接的因果关系.
- 临床评估对于区分从亚临床COVID-19感染至关重要.
- 需要进一步的研究来阐明机制并确定因果关系.
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