相关实验视频
Updated: May 7, 2026
13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
在2型疾病的杜皮卢马布治疗过程中发生的异性并发症:系统性审查
M Lazzeroni1,2, P Kemp1, W J Fokkens1
1Amsterdam Rhinology Team, Department of Otorhinolaryngology and Head and Neck Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Rhinology
|April 30, 2025
概括
杜皮卢马布治疗引起的异敏性并发症很少见,通常在治疗的早期出现. 对所有患者来说,可能不需要监测血中乙氨基细胞计数 (BEC),因为没有确定预测因子.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 皮肤病学 皮肤病学
背景情况:
- 杜皮卢马布有效治疗2型疾病,但可能导致血液中异氨基酸细胞计数 (BEC) 暂时增加.
- 这种BEC的增加引发了人们对潜在的eosinophilic并发症的担忧,包括eosinophilic granulomatosis with polyangiitis (EGPA) 和hypereosinophilic syndrome (HES) 等.
研究的目的:
- 系统地审查和汇编与dupilumab治疗相关的所有报告的异敏性并发症病例.
- 评估这些罕见不良事件的发生率,特征和结果.
主要方法:
- 在主要的科学数据库 (PubMed,Embase,Scopus,Web of Science) 进行了全面的文献搜索.
- 包括报告2型疾病治疗dupilumab患者发生eosinophilic并发症的研究.
主要成果:
- 35份报告涉及53名患者被确定,其中EGPA (24),eosinophilic肺炎 (15) 和HES (6) 是最常见的.
- 并发症发生在9周的中位数,诊断时BEC的中位数为6.38x10^9细胞/L.
- 大多数患者接受了全身性皮质类固醇治疗;89%的患者停止了dupilumab治疗,没有报告死亡.
结论:
- 与dupilumab相关的eosinophilic并发症非常罕见,通常在最初的治疗几个月内出现.
- 这些发现质疑长期BEC监测的常规需要,因为没有明确的患者模式或预测因素被确定.
相关概念视频
01:17Drugs Used in Lower Respiratory Disorders: Overview
242
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
242
01:19Antiasthma Drugs: Leukotriene Modifiers
148
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
148
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
151
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
151
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.6K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.6K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:24Asthma-III: Symptoms and Complications
2.4K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.4K