在没有药物治疗的ADHD儿童中出现功能性连接异常:诊断潜力,症状解释和调解模型
Yingzi Hu1, Yexian Zeng1, Tong Fu2
1The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou 510370, China; Institute of Psychiatry and Psychology, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China.
注意缺陷/多动障碍 (ADHD) 显示大脑连接的改变. 在左侧头骨区域的特定的塔带超连接性是ADHD诊断和治疗的关键生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 儿童精神病学 儿童精神病学
- 生物标志物发现发现
背景情况:
- 注意缺陷/多动症 (ADHD) 诊断依赖于行为症状.
- 识别客观生物标志物对于改善ADHD诊断和治疗至关重要.
研究的目的:
- 为了确定ADHD的可靠的脑电图 (EEG) 生物标志物.
- 调查ADHD儿童异常功能连接模式及其临床相关性.
主要方法:
- 收集了74名儿童的静止状态EEG数据 (33名患有多动症,41名典型发育).
- 使用连贯性的虚构部分 (ICOH) 量化功能连接性.
- 采用基于机器学习 (ML) 的支持矢量机器 (SVM) 建模,回归和调解分析.
主要成果:
- 患有多动症和多动症组表现出贝塔 (β) 带前部低连接率的降低和贝塔 (θ) 带顶部-中心高连接率的增加.
- 一个SVM分类器使用三个连接特性实现了0.89的曲线下的面积.
- 左侧面 θ 带超连接性 (C3-P7) 与注意力不集中和过度活跃/冲动性相关,调解了它们的关系.
结论:
- ADHD的特征是前双关节连接受损.
- 感官集成网络中的太频段超连接性可能会弥补前部监管缺陷.
- C3-P7 θ带连接是ADHD和神经发育障碍的有前途的诊断和机械生物标志物.
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