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Updated: May 20, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

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Ref-1氧化还原活性调节内皮细胞中规范的Wnt信号传递

Gabriella D Hartman1, Kamakshi Sishtla2, Eyram K Kpenu3

  • 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Redox biology
|April 30, 2025
PubMed
概括

向APE1/Ref-1氧化还原活性通过降低Wnt/β-catenin信号调节来抑制病态视网膜新血管化. 这揭示了对于缺血性视网膜病变 (如糖尿病视网膜病变和早产视网膜病变) 的新疗法策略.

关键词:
在APE1/Ref-1中使用.缺血性视网膜病变是一种缺血性视网膜病变.在LRP5中使用LRP5.Ref-1 氧化还原活性视网膜新血管化疗法没有信号发送.

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