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Updated: May 9, 2025

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单细胞RNA和TCR谱的分析可以识别病毒特异性T细胞的标记物

Byung-Kwan Jeong1, Young-Ae Kim2, Jung-Wook Park2

  • 1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Immunobiology
|April 30, 2025
PubMed
概括

研究人员确定了新的生物标志物来检测抗原特异性T细胞 (AST),这对于采用细胞疗法 (ACT) 至关重要. 这些标记物使得病毒抗原反应T细胞的早期隔离成为可能,从而提高了ACT的疗效.

关键词:
收养免疫疗法是一种免疫疗法.生物标志物 生物标志物有CD8阳性的T淋巴细胞.免疫治疗是一种免疫疗法.T细胞抗原受体的特异性

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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