基于瓜亚科尔的新型高性能二甲烯酸盐含有氨基卡尔多结构,用于牙科修复树脂
Yinan Sun1, Lihua Hong2, Lin Sun1
1Key Laboratory of High Performance Plastics, Ministry of Education, College of Chemistry, Jilin University, Changchun, 130012, People's Republic of China.
一种新的基于瓜亚科尔的二甲酸盐,BMHF-GMA,为牙科树脂中的Bis-GMA提供了更安全的替代品. 这种生物基树脂表现出改善的机械强度,降低了水吸附和较低的细胞毒性,使其适用于牙科应用.
科学领域:
- 牙科材料科学 牙科材料科学
- 聚合物化学 聚合物化学
- 生物材料工程 生物材料工程
背景情况:
- 由于双A的内分泌干扰特性,双A糖甲基酸盐 (Bis-GMA) 在牙科中的使用正在受到审查.
- 现有的生物基树脂替代品往往有不良的机械性能和高吸水能力.
研究的目的:
- 开发和评估一种基于瓜亚科尔的新型二甲酸盐 (BMHF-GMA),作为Bis-GMA的潜在替代品.
- 为了增强防水性,机械性质,并减少生物基牙树脂中的聚合收缩.
主要方法:
- 从一种新的基于瓜亚科尔的双 (BMHF) 中合成了9,9-bis(3-甲基-4-甘油酸甲酸) (BMHF-GMA).
- 使用BMHF-GMA制备的实验性牙科树脂 (5MHMA5T) 和使用Bis-GMA的对照树脂 (5B5T).
- 评估了双键转换,聚合收缩,收缩应力,水吸收,水溶性,细胞毒性和机械性质 (柔性强度,模量,硬度).
主要成果:
- 与商业双相比,BMHF-GMA的雌激素活性较低.
- 5MHMA5T树脂表现出与5B5T相比的可比性双键转换,减少聚合缩小和应力,以及较低的水吸附和溶解度.
- 5MHMA5T表现出优越的机械性能,在水中浸泡后基本保持.
结论:
- 新的BMHF-GMA是Bis-GMA在牙科修复应用中的有希望的替代品.
- 开发的树脂具有出色的疏水性,机械完整性和降低的细胞毒性,适用于具有挑战性的口腔环境.
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