自然生物活性化合物在MAFLD中重编胆酸代谢:多目标机制和治疗影响
Dongjie Wu1, Jing Liu1, Ziwei Guo1
1Department of Infection, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
International immunopharmacology
|April 30, 2025
概括
与代谢相关的脂肪肝疾病 (MAFLD) 在全球范围内正在上升. 传统中医药 (TCM) 化合物通过调节胆酸 (BA) 和代谢途径,在治疗MAFLD方面表现有前途.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是与肥胖和代谢综合征相关的日益严重的全球健康问题.
- 胆汁酸 (BAs) 是脂质和葡萄糖代谢和炎症的关键调节剂.
- BA与FXR和TGR5等核受体相互作用,影响MAFLD的发病性.
研究的目的:
- 系统地审查传统中医药 (TCM) 活性成分在MAFLD治疗中的分子机制.
- 分析最近应用TCM化合物用于MAFLD的进展,重点关注它们对胆酸的调节.
- 探索TCM成分如何恢复MAFLD中的代谢平衡.
主要方法:
- 对TCM活性成分和MAFLD研究的系统文献综述.
- 分析分子机制,特别是胆酸代谢和受体信号通路 (FXR,TGR5).
- 根据它们的治疗作用对TCM化合物 (沙素,黄素,多糖类,固醇) 的分类.
主要成果:
- TCM的活性成分,包括沙素,黄类,多糖和固醇,显示出对MAFLD的治疗潜力.
- 这些化合物调节胆酸合成和新陈代谢.
- 它们通过与关键信号通路相互作用而产生作用,包括FXR和TGR5.5.
结论:
- 通过向胆酸调节,TCM活性成分为MAFLD提供了一个有前途的治疗策略.
- 调节胆酸合成和受体信号通路是它们有效性的关键.
- 预计TCM化合物可以恢复MAFLD患者的代谢平衡.
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