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Updated: May 23, 2025

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对选择性雌激素受体调节剂的精确结构操纵导致了第一类 thiophene-3-benzamide 衍生物作为潜在的 ER-antagonists 没有子宫变活性

Bader Huwaimel1, Amr S Abouzied1, Abdul-Hamid Emwas2

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il 81442, Saudi Arabia; Medical and Diagnostic Research Center, University of Ha'il, Hail 55473, Saudi Arabia.

Bioorganic chemistry
|April 30, 2025
PubMed
概括

新的 thiophene-3-benzamide 和 pyrazole-4-benzamide 化合物可以选择性地向雌激素受体 (ER). 化合物5a和5d表现出强大的抗雌激素活性和最小的细胞毒性,提供潜在的乳腺癌治疗方法.

关键词:
它是一种抗雌激素.甲基-皮皮里迪诺皮拉醇塔莫西芬 (Tamoxifen) 是一种提奥芬-3-胺胺的使用方法子宫变性活动.

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