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克服电子鼻子临床研究的方法障碍,基于模拟数据的方法.

Milou L M van Riswijk1, Bastiaan F M van Tintelen2, Ruben H Lucas2

  • 1Department of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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概括

疾病患病率显著影响电子鼻子 (e-nose) 研究样本大小. 较低的患病率需要更多的数据来进行可靠的瘤查,强调需要仔细的研究设计.

关键词:
结肠直肠癌是什么意思电子鼻子 电子鼻子肺癌是一种肺癌.查检查 查检查 查检查 查检查模拟数据是模拟数据.挥发性有机化合物 挥发性有机化合物

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科学领域:

  • 生物医学工程 生物医学工程
  • 计算生物学 计算生物学
  • 在瘤学瘤学.

背景情况:

  • 使用电子鼻子 (e-nose) 技术分析的挥发性有机化合物 (VOC) 来进行瘤的非侵入性查显示出有前途.
  • 临床研究设计的指南有限,特别是关于机器学习对样本大小要求的影响.

研究的目的:

  • 为了评估瘤患病率,数据增强和电子鼻子设备的数量如何影响样本大小,需要准确的预测模型.
  • 为在临床环境中优化电子鼻子研究设计提供数据驱动的见解.

主要方法:

  • 基于真实世界数据的模拟电子鼻子呼吸测试数据.
  • 分析不同瘤发病率 (5%-50%) 和数据增强对模型性能的影响.
  • 使用单值分解,随机森林和卷积神经网络开发预测模型.

主要成果:

  • 较低的瘤患病率大大增加了样本大小要求;5%的患病率需要高达50%患病率的五倍以上的数据来保持稳定的模型性能.
  • 不同电子鼻子设备的模型性能各不相同,多设备集成需要更大的样本大小.
  • 为了保持稳定的性能,每种设备在50%的患病率下需要大约400个数据点,在5%的患病率下需要2100个数据点.

结论:

  • 瘤患病率和电子鼻子设备的数量是决定样本大小要求的关键因素.
  • 在电子鼻子研究中,尽量减少设备的变化,并确保每个设备的适当病例/对照样本对于可靠的预测性能至关重要.