在没有疼痛的周周排卵期期间,在患有原发性异常症的妇女中,大脑形态变化和相关的功能连接和滞后结构发生在无疼痛的周周排卵期
Xing Su1, Huiping Liu2, Hong Wang3
1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics and Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, China; Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, Xi'an, Shaanxi, China; Rehabilitation Medicine Department, The First Affiliated Hospital of Xi'an Jiaotong University, China.
原发性经期障碍 (PDM) 涉及与疼痛感知和情绪调节相关的大脑结构变化. 这些变化与功能网络的变化相关,为PDM疼痛管理提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 疼痛研究 疼痛研究
背景情况:
- 初级经经障 (PDM) 的特点是没有病理性的月经疼痛,涉及中枢神经系统 (CNS) 的改变.
- 以前对PDM大脑变化的研究主要集中在功能方面,对结构形态学的研究有限,样本小.
- 在PDM中,大脑结构变化,功能变化和前列腺素水平之间的关系尚不清楚.
研究的目的:
- 研究与健康对照组 (HC) 相比,PDM患者的灰质体积 (GMV) 差异.
- 探索PDM中结构性大脑变化和功能性变化之间的合.
- 检查PDM中结构变化和前列腺素水平之间的关联.
主要方法:
- 基于voxel的形态测量 (VBM) 用于分析59名PDM患者和56名HC患者的GMV在无疼痛的周周发卵期期间.
- 时间延迟分析被用来评估改变的大脑区域之间的定向信号模式.
- 基于网络的统计数据 (NBS-predict) 用于检查功能分离的变化.
主要成果:
- 在与情绪调节和疼痛反相关的区域,PDM患者的GMV增加,在疼痛感知和注意力区域的GMV降低.
- 左中皮质被确定为疼痛预测,注意力和PDM下降疼痛调节的关键节点.
- 发现结构性改变与大脑网络内的功能整合和分离的变化有关.
结论:
- 在PDM中,结构性大脑变化与改变的情绪和疼痛处理以及网络集成有关.
- 这些发现表明,在PDM中,结构性和功能性大脑变化之间存在联系.
- 这些见解有助于了解PDM中枢神经系统机制,并可能为临床疼痛干预提供信息.
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