由于料限制导致的产后早期超血症的奶牛的免疫代谢概况与健康的奶牛或患有炎症性疾病的奶牛不同
J K Drackley1, H M Dann1, G Bertoni2
1Department of Animal Sciences, University of Illinois, Urbana, IL 61801.
Journal of dairy science
|April 30, 2025
概括
牛的产后超血症可以在没有炎症的情况下发生,因为健康的被限制食的牛显示出最小的炎症标志物. 这表明免疫激活并不总是需要在过渡到哺乳期期间发展超血症.
科学领域:
- 兽医免疫学 兽医免疫学
- 动物的新陈代谢
- 乳牛健康 乳牛健康 乳牛健康
背景情况:
- 从怀孕过渡到哺乳期是奶牛的关键时期,通常因免疫激活和炎症而复杂.
- 产后超血症是一种代谢障碍,经常与炎症有关,但其独立发生仍在争论中.
研究的目的:
- 为了研究和比较健康奶牛,受限养奶牛和患有周周发炎性疾病的奶牛血清中的免疫代谢特征.
- 为了确定产后血症是否可以独立于免疫激活而发展.
主要方法:
- 血清样本采集来自多胞胎霍尔斯坦牛 (n=32) 的血清样本,分为三个组:健康的对照组 (CON),受限料的对照组 (FR) 和患有周周发炎性疾病 (PID) 的对照组.
- 分析了免疫代谢标志物,包括白蛋白:球蛋白比率,β-胡卜素,哈普托格洛宾,BHB,葡萄糖,胆固醇和肝酶.
- 牛从干旱期到早期哺乳期 (在牛奶中长达14天) 进行了监测.
主要成果:
- 与健康的奶牛相比,患有周周发炎性疾病 (PID) 的奶牛表现出较低的白蛋白:球蛋白比率和β-胡卜素分娩前.
- 与PID奶牛相比,受限料 (FR) 的奶牛在产后7天显示出较低的葡萄糖和胆固醇,但高的非化脂肪酸和BHB.
- 健康的限制料的奶牛 (FR) 显示出极少的炎症迹象,这表明超血症可以独立于免疫激活发生.
结论:
- 在健康的,被限制食的奶牛中,产后血似乎在很大程度上独立于免疫激活和炎症.
- 过渡期的代谢障碍可能是由于营养挑战 (食限制) 而不会同时出现炎症状况.
- 针对乳牛的有针对性的管理策略,需要进一步研究超血症的独特机制.
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