相关实验视频

Updated: May 20, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

CMTM3 通过CLTC稳定和调节VE-cadherin促进结肠炎相关的致癌

Rongbin Li¹, Yuan Liu¹, Qiyao Liu²

¹Department of Immunology, School of Basic Medical Sciences and NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China; Peking University Center for Human Disease Genomics, Beijing, China.

Cellular and molecular gastroenterology and hepatology

|April 30, 2025

概括

化学基因样因子样MARVEL跨膜域含有成员3 (CMTM3) 通过增加血管透性促进结肠炎相关的结肠癌 (CAC). 抑制CMTM3可能通过减少大肠炎的严重程度来为CAC提供治疗策略.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

炎症性肠病 (IBD) 增加了结肠炎相关结肠癌 (CAC) 的风险.
化学基因样因子样MARVEL跨膜域含有成员3 (CMTM3) 涉及炎症和癌症,结肠癌中甲基化升高.
CMTM3在CAC发展中的作用需要进一步研究.

研究的目的:

调查CMTM3在小鼠中诱导的大肠炎相关结肠癌 (CAC) 的氧甲 (AOM) /硫酸德克斯 (DSS) 的发展中的作用.
阐明CMTM3影响大肠炎和CAC进展的潜在机制.

主要方法:

野生类型和Cmtm3缺乏的小鼠中CAC的阿佐西甲 (AOM) /德克斯硫酸 (DSS) 模型.
评估疾病表型,包括体重,疾病活动指数 (DAI),结肠长度和组织学.
涉及免疫细胞透,肠道透性,免疫光,西斑,免疫沉和拉下测试的机制研究.

主要成果:

CMTM3 缺乏或内皮细胞特异性去除Cmtm3显著抑制大肠炎的发展和CAC.
在CMTM3中,CMTM3通过通过克拉素依赖的血管内皮-素的降低调节来增加血管透性,从而加剧结肠炎.
CMTM3 与克拉特林重链相互作用,抑制其无处化和蛋白质酶体降解.

结论:

通过增加血管透性,CMTM3通过加剧结肠炎来促进CAC.
针对CMTM3或其下游通路,如血管透性,为CAC.提供了潜在的治疗策略.

关键词:

屏障功能屏障功能在CMTM3中,CMTM3是CMTM3中的一个.大肠炎相关的结肠癌性结肠炎是一种

更多相关视频

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer

Published on: October 13, 2023

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...