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大脑休息状态功能活动与肥胖之间的关联:双向的门德尔随机化研究

Zhaoyi Chen¹, Jinkun Wang², Tianli Lyu¹

¹Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China.

Clinical nutrition ESPEN

|April 30, 2025

概括

遗传分析表明,体重会影响大脑活动,反之亦然. 这项研究阐明了肥胖和功能性大脑变化之间的因果关系,特别是视觉和默认模式网络.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
公共卫生公共卫生

背景情况:

肥胖和超重与大脑活动模式的改变有关.
人体体重和大脑功能之间的因果关系尚未得到充分理解.

研究的目的:

通过使用遗传数据,研究体重和大脑功能活动之间的双向因果关系.

主要方法:

进行了一项双向的双样本孟德尔随机化研究.
对191个功能性脑成像表型和肥胖特征的全基因组关联研究数据进行了分析.
使用了多种统计方法,包括逆方差加权和MR Egger,并进行了性和异质性分析.

主要成果:

视觉网络区域 (calcarine,lingual,cuneus) 的自发性大脑活动增加因果关系影响身体体重.
体重对默认模式中的自发大脑活动和中央执行网络区域 (前,角,环状,状回旋) 有因果影响.

结论:

这项研究提供了遗传证据,证明体重与大脑功能活动之间存在因果关系.
研究结果突出了特定的大脑网络和参与这种双向关系的区域.

关键词:

大脑休息状态 - 功能活动的功能活动.门德尔的随机化肥胖问题肥胖问题

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