怀孕期间母亲的运动:性别特异性影响后代的记忆和母亲的剥夺效应
Guilherme Salgado Carrazoni1, Pâmela B Mello-Carpes1
1Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana 97501-970, Brazil.
Neuroscience letters
|April 30, 2025
概括
孕妇在怀孕期间进行运动,特别是保持或开始运动,可以保护男性后代免受早期生活压力引起的记忆缺陷. 这种干预也对大脑的氧化平衡产生了积极的影响.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 行为科学 行为科学
背景情况:
- 母亲剥夺 (MD) 是早期生活压力对大脑和记忆的影响的一个模型.
- 母亲运动 (ME) 影响后代的神经发育和行为.
研究的目的:
- 为了调查在怀孕期间不同的孕产妇运动 (ME) 协议是否能保护后代免受MD诱导的记忆缺陷.
- 评估ME对海马体氧化平衡对MD暴露后代的影响.
主要方法:
- 成年Wistar大鼠接受了各种ME协议 (不运动,怀孕前,减少,平等,孕期运动).
- 后代在出生后暴露于控制 (CT) 或母性剥夺 (MD) 条件.
- 对象识别记忆测试和海马脂类过氧化/酶水平在90天后被测量.
主要成果:
- 医学医学在男性,但不是女性的后代中引起记忆缺陷.
- 大多数ME协议可以预防MD诱导的记忆缺陷;只有怀孕前的运动组在男性中显示出缺陷.
- MD没有改变海马体脂质过氧化;特定的ME协议 (PRE,EQUAL) 增加了catalase水平.
结论:
- 在怀孕期间保持或开始进行母体炼对于减轻MD诱导的记忆障碍至关重要,特别是在男性后代中.
- 孕妇在怀孕期间的运动可以保护她们免受早期与压力相关的认知缺陷,并影响海马体的氧化压力标志物.
相关概念视频
Spermatogenesis
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...


