患有结石的患者的尿道微生物群:系统性审查和元分析
Microbial pathogenesis
|April 30, 2025
概括
这项研究发现,与健康人相比,结石 (KS) 患者的尿液微生物多样性较低. 像Acinetobacter和Corynebacterium这样的特定细菌在KS患者中更为丰富,这表明肠道微生物群和结石形成之间存在联系.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 基因组学就是基因组学.
背景情况:
- 结石 (KS) 的患病率在全球范围内正在增加.
- 建议尿液微生物与KS之间存在关联,但机制尚不清楚.
- 了解尿液微生物群的差异对于KS病变的发生至关重要.
研究的目的:
- 为了研究KS患者的尿液微生物群组成.
- 为了确定KS患者和健康对照人群之间的微生物群的差异.
- 探索尿液微生物在结石发育中的作用.
主要方法:
- 7项研究的系统综述和元分析.
- 在PubMed,Embase和Web of Science数据库中进行了搜索.
- 在族群,属和物种层面分析了α-多样性和微生物群的丰富性.
主要成果:
- 与对照组相比,KS患者的α-多样性 (香农指数) 显著较低.
- 在KS患者中增加了Acinetobacter,Pseudomonadota和Corynebacterium的丰富性.
- 在KS患者中减少了Bacilliota和Bacteroides的丰度.
结论:
- 尿路微生物群的组成在KS患者和健康个体之间有显著差异.
- 这些差异与结石的病原性有关.
- 饮食修改或抗生素可能有助于预防KS.
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