侵入性产前检测,诊断和堕胎的趋势 对于胎儿积症
Elizabeth Arruda1, Jamison Lee2, Kayla Shine1
1College of Medicine, Medical University of South Carolina, Charleston, South Carolina.
American journal of perinatology
|April 30, 2025
概括
无细胞DNA (cfDNA) 查已经减少了侵入性产前检测和转移的指示. 异常cfDNA结果导致早期诊断和堕胎,但确认通常发生在第二个三个月的晚期.
科学领域:
- 产科和妇科 产科和妇科
- 产前诊断 在产前诊断
- 遗传学 遗传学 是一个
背景情况:
- 在例行产前护理中引入无细胞DNA (cfDNA) 查,改变了胎儿形症的诊断途径.
- 自cfDNA实施以来,了解指示,诊断产量和诊断和堕胎时间的趋势至关重要.
研究的目的:
- 评估cfDNA查对产前测试对形积分症的影响.
- 分析指示的趋势,诊断产量,以及诊断和终止怀孕的时间.
主要方法:
- 从2010年至2022年对入侵性产前诊断程序的观察后期研究.
- 评估临床变量,包括妊娠年龄,指示,结果和妊娠结果.
- 描述性统计数据以描述患者样本的特征.
主要成果:
- 侵袭性手术在cfDNA引入后显著减少,症状从较晚的孕产妇年龄转移到异常超声检查结果.
- 异常的cfDNA查与早期的诊断测试 (15.3 vs. 17.8周) 和更高的形积分病检测率 (60.4% vs. 13.2%) 有关.
- 尽管较早的cfDNA查,诊断和流产形性经常发生在第二个三个月 (15.5vs19.3周的流产).
结论:
- cfDNA查减少了侵入性的产前诊断程序和改变了测试指示.
- 异常cfDNA查改善了诊断产量,并使早期诊断和确认后堕胎成为可能.
- 在许多地区,在妊娠年龄范围内及时诊断堕胎仍然存在挑战.
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