小脑活动影响远距离皮层生理学和突触可塑性在人类围膜-运动通路与机动行动相关
Elana R Goldenkoff1, James A Brissenden2, Taraz G Lee2
1School of Kinesiology, University of Michigan, Ann Arbor, USA.
概括
小脑刺激 (iTBS) 会改变大脑的可塑性. 间歇性爆刺激小脑减少了运动网络中的可塑性,这表明它在大脑连接中起着调节作用.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑的可塑性 大脑的可塑性
背景情况:
- 自发运动依赖于相互连接的大脑区域的可塑性:小脑 (CB),初级运动皮质 (M1) 和后壁皮质皮质 (PPC).
- 假设CB在调节PPC-M1通信中的作用是假设的,但缺乏人类的直接因果证据.
研究的目的:
- 研究如何暂时改变小脑活动会影响PPC-M1的连接性和可塑性.
- 评估小脑在运动网络中调节神经可塑性的因果作用.
主要方法:
- 一个在人体内设计,使用间歇性达爆发刺激 (iTBS) 应用于小脑或视觉皮层.
- 随后,赫比亚式的皮质配对关联刺激 (cPAS) 应用于状运动电路.
- 通过使用跨磁刺激,通过运动唤起的潜能 (MEP) 测量运动皮层刺激能力.
主要成果:
- 大脑小细胞iTBS显著降低了表皮运动电路中cPAS诱导的可塑性,由降低的MEP表示.
- 这种效应是小脑刺激的特征,因为对照条件 (视觉皮层iTBS,单独cPAS) 没有产生类似的减少.
- 这些发现表明,通过小脑输入选择性调节远端神经活动.
结论:
- 小脑活动可以通过异质突触性转塑性修改连接的运动网络中的神经可塑性.
- 这项研究提供了小脑在调节PPC-M1运动网络内的通信方面的调节作用的因果证据.
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