甲胺皮酸盐用于治疗和预防复发性尿路感染:一个范围审查协议
Abhisekh Chatterjee1, Iihan Ali2, Franklyn Wong2
1Imperial College School of Medicine, Imperial College London, London, UK abhisekh.chatterjee20@imperial.ac.uk.
BMJ open
|April 30, 2025
概括
本范围审查概述了评估甲胺皮酸盐作为复发性尿路感染 (rUTIs) 的非抗生素治疗方法的方法. 它旨在绘制现有证据,并确定这一重要的RUTI管理选项的研究缺口.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 证据综合 证据综合
背景情况:
- 经常性泌尿道感染 (rUTIs) 构成了重大的健康挑战,抗菌素耐药性日益增加,需要替代治疗.
- 甲胺基酸盐是一种非抗生素的尿液消毒剂,在RUTI预防中引起了人们的注意.
- 目前关于甲胺普拉特的疗效的证据有限,特别是在脆弱人群中.
研究的目的:
- 对RUTIs对甲胺皮酸盐的现有文献进行全面的范围审查.
- 为了绘制证据基础,确定常见的副作用,并突出显示未来的研究方向.
- 为提供最新的评估甲胺皮酸盐作为非抗生素管理选项.
主要方法:
- 协议是根据阿克西和奥马利框架开发的.
- 在多个数据库 (MEDLINE,Embase,Scopus等) 中进行搜索. 直到2024年8月,没有语言限制.
- 包括多样化的研究设计 (RCT,队列,观察) 和灰色文献用于全面的证据映射.
主要成果:
- 数据提取和分析将利用描述性统计和叙事性主题分析.
- 两名独立审查员将使用Covidence评估研究资格.
- 该审查将综合有关甲胺皮酸盐在各种患者群体中的有效性,安全性和应用的研究结果.
结论:
- 这一范围审查将提供一个全面的概述的甲胺皮酸盐对于rUTIs.
- 它将确定知识差距,并指导未来在非抗生素尿路感染管理方面的研究.
- 这些发现将为临床实践和有关甲胺基酸盐使用的政策提供信息.
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