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队列概况:测量不良怀孕和新生儿先天性结果 (MANGO) 在肯尼亚的研究

John M Humphrey¹, Audrey Chepkemoi², Steven Brown³

¹Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA humphrjm@iu.edu.

|April 30, 2025

概括

曼戈研究在肯尼亚建立了一个药物监测系统,以监测孕妇抗逆转录病毒治疗的安全性. 该模型解决了实施障碍,显示了在类似环境中复制的潜力.

科学领域:

全球健康全球健康
药物监督药物监督药物监督
孕产妇和儿童的健康

背景情况:

在怀孕期间用于抗逆转录病毒治疗 (ART) 的药物监测 (PV) 系统至关重要,但在高艾滋病毒负担,低资源环境中缺乏.
这些系统的实施策略有限,这阻碍了对艾滋病毒感染的孕妇 (WLH) 的安全评估.

研究的目的:

在肯尼亚实施和评估测量不良怀孕和新生儿先天性结果 (MANGO) 研究.
在资源有限的环境中,解决药物监测中存在的缺口,以确保在孕期怀孕和孕妇怀孕期间的ART安全性.

主要方法:

在MANGO研究中,Moi教学和转诊医院 (MTRH) 的艾滋病毒感染者 (WLH) 和非艾滋病毒感染者 (WNLH) 孕妇参与了该研究.
使用了两个队列:C1 (前性,匹配的WLH和WNLH参加产前护理) 和C2 (截面,所有分娩包括那些不参加产前护理的人).
确定了分娩结果,包括死胎,早产,低出生体重和先天异常.

主要成果:

在2020年10月至2023年9月期间,记录了超过24,205次交付.
关键发现包括2.6%的死产率,17.2%的早产,15.1%的低出生体重婴儿,以及73.9/10,000例出生的主要先天性异常患病率.
通过伙伴关系,培训和激励,克服了缺乏国家光伏政策和员工流动等实施障碍,导致光伏制度化.

结论:

在MANGO研究中,在资源有限的环境中成功实施了一种药物监测模型.
多方面的MANGO战略表明,在全球范围内改善ART安全监测的复制潜力.
需要进一步的研究来探索MANGO模型在不同环境中的更广泛的实施机会.

关键词:

不良事件不良事件不良事件流行病学研究流行病学研究艾滋病毒和艾滋病病毒实施科学实施科学医学教育和培训医学教育和培训怀孕怀孕怀孕怀孕

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