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人类乳头瘤病毒基因型分布及其与内皮质瘤,疫苗接种和种族之间的相关性

Rita Abi-Raad¹, Tong Sun¹, Uma Krishnamurti¹

¹Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Journal of the American Society of Cytopathology

|April 30, 2025

概括

人类乳头瘤病毒 (HPV) 的非16/18基因型比HPV 16/18更常见,特别是在高度子宫病变中. 这表明需要更广泛的HPV基因型定型和针对其他HPV类型的疫苗,以改善预防.

科学领域:

妇科瘤学妇科瘤学
病毒学病毒学
公共卫生公共卫生

背景情况:

子宫癌主要是由高风险的人类乳头瘤病毒 (HPV) 引起的,其中基因型16和18是最常见的.
开发HPV疫苗是为了降低宫癌的发生率.

研究的目的:

为了比较HPV基因型16/18和非16/18在患有高度状内皮病变 (HSIL) 和非典型状细胞 (ASC-H) 的患者中的患病率.
分析跨不同种族和HPV疫苗接种状态的HPV基因型流行率.

主要方法:

274名HSIL或ASC-H诊断的患者的回顾性审查.
对高风险HPV阳性和HPV基因定型数据的分析.
根据损伤程度,种族和疫苗接种情况,比较HPV 16/18和非16/18的流行情况.

主要成果:

非-16/18型HPV在ASC-H (68%) 病例中明显比HSIL (50%) 病例更为普遍.
非-16/18型HPV在没有高度内皮质瘤 (IN2+) 的病例中更为常见 (69%),但在IN2+病例中也存在56%.
非-16/18型HPV在所有族群中患病率更高,非白人和接种疫苗的妇女患病率更高的趋势.

结论:

非16/18型HPV基因型比16/18型HPV更为普遍,即使是在高度的宫病变中.
在非白人和接种疫苗的人群中观察到向非16/18基因型的转变.
这些发现支持扩大HPV基因型和更广泛的HPV疫苗的需要,以加强宫癌的预防,特别是在特定的种族群体.

关键词:

民族身份民族身份基因型基因型基因型人类乳头瘤病毒 (HPV)皮质内瘤是什么?疫苗疫苗疫苗疫苗

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