在不接受机械通风的老年人住院期间口腔微生物组的变化
Kimberly Paige Rathbun1, Mary Lou Sole2, Shibu Yooseph3
1Kimberly Paige Rathbun is a postdoctoral research fellow at Moffitt Cancer Center Department of Health Outcomes and Behavior, Tampa, Florida.
概括
来自熟练护理机构 (SNFs) 的住院老年人与来自家庭的老年人相比,口腔健康状况较差,口腔微生物组也不同. 口腔细菌和多样性的这些差异在住院期间变得更糟.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 口腔健康 口腔健康
背景情况:
- 口腔细菌可能是致病的,在住院期间会发生变化,这增加了老年人患并发症的风险.
- 熟练护理设施 (SNFs) 居民是潜在的口腔健康挑战的脆弱人群.
研究的目的:
- 基于医院前住院 (SNF与家庭) 的入院老年人的口腔微生物组进行比较.
- 评估这些患者在住院期间口腔微生物组的变化.
主要方法:
- 对46名住院成年人 (≥65岁) 的前性观察性研究,不接受机械通风.
- 使用口腔健康评估工具评估口腔健康;通过唾液的16SrRNA测序分析口腔微生物组.
- 评估了分类学组成,相对丰富性,α-多样性 (香农指数) 和β-多样性 (布雷-库蒂斯).
主要成果:
- 来自SNF的患者有较高的认知障碍,妄想,虚弱和并发病率.
- 接受SNF治疗的患者表现出更多与口腔疾病相关的细菌,较低的α-多样性和较高的β-多样性.
- 在住院期间,口腔微生物群的多样性随着时间的推移发生了显著变化,其中包括群体相互作用效应.
结论:
- 从SNF入院的住院老年人面临着严重的口腔微生物和口腔健康差异.
- 这些发现凸显了针对SNF居民进行有针对性的口腔护理干预的必要性.
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