使用Sonoclot分析仪在患有散布血管内凝血的患者中管理凝血
1Peng Wan is a chief physician, Department of Critical Care Unit, First Clinical Medical College of Three Gorges University, Yichang, Hubei, China.
概括
索诺克洛特分析仪改善了分布式血管内凝血 (DIC) 患者的30天生存率. 这种工具还减少了抗凝血和输血的需求,特别是在败血症和热中风病例中.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 分布式血管内凝血 (DIC) 管理缺乏经过验证的改善结果的工具.
- 支持Sonoclot分析仪在DIC中的临床实用性的证据有限.
研究的目的:
- 评估基于Sonoclot分析仪的算法在改善DIC患者短期预后方面的有效性.
- 为了比较Sonoclot引导的方法和传统的凝血试验之间的临床结果.
主要方法:
- 一项前性研究涉及279名明显DIC患者,分为常规凝血试验 (CCA) 和Sonoclot组.
- 收集和分析了抗凝血,输血和30天生存时间的数据.
- 两组之间生存率和资源利用率的比较.
主要成果:
- 与CCA组相比,Sonoclot组的30天生存率 (78.45%) 显著高于CCA组 (63.64%;P = .02).
- 氨酸剂量,抗凝血持续时间和重大出血率在索诺克洛特组明显较低 (P < .001).
- 在索诺克洛特组 (P ≤ .03) 中,输血需求 (新鲜冷血,血小板,冷沉积物) 显著降低.
结论:
- 索诺克洛特分析仪显示出作为指导DIC凝血管理的有价值工具的潜力.
- 基于Sonoclot的算法可能会改善临床结果,特别是对于中度严重败血症或热中风的DIC患者.
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