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Updated: May 9, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

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F-box蛋白 FBXO32 无处不在并稳定D型环林,以驱动癌症的进展

Feng Li1,2,3, Hongqiang Yu1, Yujun Zhang1

  • 1Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University, Chongqing, China.

Nature communications
|April 30, 2025
PubMed
概括

这种E3泛基因酶FBXO32 (atrogin-1) 稳定了环林D蛋白,促进了癌症. 针对这种FBXO32-cyclin D相互作用可能会改善癌症治疗,包括CDK4/6抑制剂.

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