在抗TNF治疗期间患结核病的患者中进行HLA B亚型分析
Fatih Albayrak1, Gökhan Keser2, Serdar Oztuzcu3
1Department of Rheumatology, Gaziantep University Hospital, Osmangazi Neighborhood, Şehitkamil, Gaziantep, Turkey. drfalbayrak@yahoo.com.
这项研究调查了在抗瘤坏死因子 (TNF) 治疗期间患有结核病 (TB) 的患者的人类白细胞抗原B (HLA-B) 亚型. 在这个特定的患者群体中,没有证实显著的HLA-B亚型关联.
科学领域:
- 免疫遗传学 免疫遗传学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 抗瘤亡因子 (TNF) 疗法对于治疗自身免疫性疾病至关重要.
- 服用抗TNF药物的患者可能对感染,包括结核病 (TB) 的易感性发生变化.
- 人类白细胞抗原B (HLA-B) 亚型已知会影响免疫反应和疾病易感性.
研究的目的:
- 在接受抗TNF治疗期间患有结核病的患者中评估HLA-B亚型.
- 为了将这些HLA-B亚型与社区获得的结核病患者,没有结核病的抗TNF患者和健康对照者的HLA-B亚型进行比较.
主要方法:
- 从四个不同的组的血液样本中对HLA-B亚型的遗传分析.
- 使用LIFECODES HLA-B eRES SSO打字套件进行HLA-B打字.
- 包括35名社区获得的结核病患者,47名抗TNF-TB患者,61名抗TNF (非结核病) 患者和40名健康对照.
主要成果:
- 在四组中观察到HLA-B5,HLA-B8,HLA-B27和HLA-B38的HLA-B亚型有显著差异.
- 在患有结核病的抗TNF患者中,HLA-B8的频率最高,但在校正后,这没有达到统计学意义.
- 在两个抗TNF组中,HLA-B27升高,归因于结性脊髓炎患者.
结论:
- 这是第一个分析HLA-B亚型在抗TNF患者发展结核病的研究.
- 该研究没有证实HLA-B8和社区获得的结核病在抗TNF治疗的背景下之前建议的关联.
- 需要进行更大规模的多民族研究,才能在这个患者群体中确定HLA-B亚型的关联.
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