识别与长期COVID的明显表现相关的可溶性生物标志物
Yu Gao1, Curtis Cai1, Sarah Adamo1,2
1Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Nature immunology
|April 30, 2025
概括
长期冠状病毒病 (COVID) 涉及微妙的免疫变化,包括改变的T细胞和较低的中和抗体对抗SARS-CoV-2. 生物标志物将呼吸困难与炎症联系起来,可能有助于长期COVID诊断和治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 病毒学 病毒学
背景情况:
- 长期冠状病毒病 (COVID) 是SARS-CoV-2感染后的一个复杂疾病.
- 它的确切原因和免疫系统的影响仍然不清楚.
研究的目的:
- 在长期COVID患者中分析免疫系统和血蛋白质组.
- 确定用于诊断和治疗的生物标志物.
主要方法:
- 免疫细胞和血蛋白质组的超敏感分析.
- 对来自瑞典和英国的地理独立群体的分析.
- 对T细胞和抗体标位的表型分析.
主要成果:
- 没有发现一致的定量免疫细胞或T细胞差异.
- 长期COVID患者的SARS-CoV-2中和抗体标位较低.
- 在长期COVID中发现的CD8+T细胞上PD-1和TIM-3的表达增加.
- 血生物标志物将呼吸困难与炎症网络 (CCL3,CD40,IKBKG,IL-18,IRAK1) 以及失调的通路联系起来.
结论:
- 长期COVID表现出微妙的免疫失调,而不是广泛的定量变化.
- 已识别的血生物标志物和途径为长期COVID诊断和治疗策略提供了潜力.
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