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Updated: Jun 14, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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转录组变化包括p53调节失调的主要DNMT3A突变细胞用于转化

Erin M Lawrence1,2, Amali Cooray1,2, Andrew J Kueh1,2,3,4

  • 1Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

EMBO reports
|April 30, 2025
PubMed
概括

DNMT3A突变通过损害血液细胞干细胞中的DNA甲基化和p53信号,加速小鼠淋巴瘤的发展. 这导致自我更新的增加和恶性转变的更高风险.

关键词:
基因甲基化 DNA 甲基化在DNMT3A中,它是DNMT3A.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.基因工程是一种基因工程.血液学癌症 血液学癌症

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