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Updated: May 7, 2026

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使用由人类诱导的多能干细胞制成的有机体进行毒性测试,这些细胞被设计为报告氧化应激

Mona Elhendawi1, Melanie L Lawrence1, Jamie A Davies2

  • 1Deanery of Biomedical Sciences and Centre for Engineering Biology, University of Edinburgh, Edinburgh, UK.

Methods in molecular biology (Clifton, N.J.)
|April 30, 2025
PubMed
概括

研究人员设计干细胞来检测氧化应激,一种有毒物质反应. 这些细胞形成了脏器官,用于选化合物,证明了毒性测试的新方法.

关键词:
药物查是指对药物进行查.人类诱导的多能干细胞 (hiPSC)脏的有机体是脏的有机体.毒性 毒性 毒性器官类动物 器官类动物氧化应激是一种氧化应激.这是一种脏有机物.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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