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纵向体重指数轨迹与表型年龄加速的关联:基于增长混合模型的横截面研究
Yalan Liu1, Li Zhang2, Zhaofeng Jin3
1Nanan District Center for Disease Control and Prevention, Chongqing, 401336, China.
GeroScience
|April 30, 2025
概括
慢性肥胖与表型较老有关,而保持稳定的体重指数 (BMI) 与表型较年轻有关. 早期和最近的BMI变化显著影响表型年龄加速.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 生物统计学 生物统计学
背景情况:
- 关于体重变化与衰老之间的关系存在不一致的发现.
- 现型年龄加速 (PhenoAgeAccel) 为生物衰老提供了一个新的指标.
- 了解BMI轨迹对衰老的影响对于公共卫生干预至关重要.
研究的目的:
- 研究身体质量指数 (BMI) 轨迹与表型年龄加速 (PhenoAgeAccel) 之间的关联.
- 分析早期和最近的BMI变化对PhenoAgeAccel的影响.
- 为了澄清体重动态和生物衰老之间的复杂关系.
主要方法:
- 使用国家健康和营养检查调查数据 (2005-2018) 对于50岁及以上的参与者.
- 采用增长混合模型来识别不同的BMI轨迹.
- 应用了线性和多项逻辑回归,并对BMI变化进行值效应分析.
主要成果:
- 确定了四个BMI轨迹:稳定的体重 (29.07%),中年增长 (24.31%),晚年增长 (32.22%),和慢性肥胖 (14.41%).
- 慢性肥胖与更高的PhenoAgeAccel (β=4.34) 有关.
- 早期的BMI变化>6%和最近的BMI变化>2%与加速衰老有关.
结论:
- 长期的慢性肥胖与表型上年龄较大有关.
- 稳定的体重与表型更年轻有关.
- 特定的BMI变化值影响表型衰老,突出显示了体重管理在整个生命中的重要性.
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