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童年创伤和成年期的负面事件之间的相互作用对刺激性肠综合征的发展和严重性的影响

Zhiyu Dong^1,2, Xiaomei Wang³, Liqian Xuan⁴

¹Department of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.

BMC gastroenterology

|April 30, 2025

概括

儿童时期的情绪创伤加剧了成年人的负面事件对刺激性肠综合征 (IBS) 症状严重程度和生活质量的影响. 这种相互作用显著影响有童年创伤史的IBS患者.

科学领域:

胃肠病学胃肠病学
精神病学是一个精神病学.
精神病体医学是一种精神病体医学.

背景情况:

童年创伤和成年人的负面生活事件与刺激性肠综合征 (IBS) 症状严重程度有关.
这些不利因素对IBS的综合影响仍未得到充分研究.

研究的目的:

检查童年创伤和成人负面事件在IBS发展,严重程度和生活质量之间的相互作用.
了解生命早期的逆境如何改变IBS中后来的压力因素的影响.

主要方法:

70名健康对照和88名IBS患者 (罗马标准) 的回顾性分析.
使用了童年创伤问卷 (CTQ),生活事件量表 (LES),IBS-生活质量 (IBS-QOL) 和IBS-严重性评分系统 (IBS-SSS).
使用逻辑和线性回归来评估相互作用效应.

主要成果:

女性性别,童年情绪虐待/忽视和成人负面事件与更高的IBS患病率相关.
在IBS患者中,童年情绪虐待/忽视和成人负面事件独立地恶化了症状和生活质量.
在IBS严重程度和生活质量方面发现了显著的相互作用,成人负面事件在患有童年情绪创伤的人中产生了更大的影响.

结论:

童年情绪创伤和成人负面事件与IBS的发展,严重程度的增加和生活质量的降低有关.
童年情绪创伤放大了成年人的负面事件对IBS症状严重性和生活质量的有害影响.

关键词:

童年创伤童年创伤童年创伤刺激性肠综合征是什么意思成年时期的负面事件.

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