身体健康预测化学放射治疗后的食道切除术后并发症:一个试点研究
Chien-Hung Chiu1, Wei-Yang Chang2, Lan-Yan Yang3
1Division of Thoracic Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
BMC sports science, medicine & rehabilitation
|April 30, 2025
概括
低的手术前体能,特别是ASMI-V̇O2peak/SMM产品 (AV̇P),显著预测了食道切除术后食道癌的主要并发症. 识别低AV̇P的患者可以指导术后管理,以改善结果.
科学领域:
- 在瘤学瘤学.
- 外科手术的结果
- 身体适应性评估 身体适应性评估
背景情况:
- 化学放射治疗后的食道切除术为食道状细胞癌提供了有利的瘤结果.
- 手术后的并发症很常见,并且影响食道切除术后的生存率.
- 确定预先预测并发症的术前因素对于患者管理至关重要.
研究的目的:
- 为了确定与食道切除术后重大术后并发症相关的身体健康因素.
- 评估食道癌症患者各种健身参数的预测值.
主要方法:
- 72名食道状细胞癌患者进行食道切除术 (2020-2022) 的回顾性分析.
- 多变量后勤回归和基于树的学习,以确定重大术后并发症的预测因素.
- 评估包括体重,BMI,峰值氧气消耗 (V̇O2peak),骨肌量 (SMM),尾骨肌指数 (ASMI) 和ASMI-V̇O2peak/SMM产品 (AV̇P).
主要成果:
- 40.2%的患者经历了严重的术后并发症.
- 低体重,BMI,V̇O2peak,V̇O2peak/SMM,ASMI和AV̇P与完整模型中的并发症有关.
- 低AV̇P是储蓄型模型中唯一显著的预测因素 (P < 0.01).
- 基于树的分析确定了AV̇P,EqO2nadir和手握力作为关键预测因素,AV̇P显示了最强的相关性.
结论:
- 低AV̇P是食道切除术后重大术后并发症的强有力的预测因素.
- 术前对身体健康的评估,特别是AV̇P,可以识别高风险患者.
- 这种查可以为术后策略提供信息,以减轻并发症并改善患者的治疗结果.
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