叶酸是否与肺癌的发展有关? 在NHANES中的横截面研究
Binbin Li1, Fei Xu2, Xuxiang Lu2
1The first school of clinical medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
BMC pulmonary medicine
|April 30, 2025
概括
叶酸形式,如5-甲基四基叶酸和5,10-甲基基叶酸与肺癌 (LC) 风险有关. 这些和其他叶酸的特定水平可能会影响LC的发展,这需要进一步调查.
科学领域:
- 营养生物化学 营养生物化学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 叶酸是癌症治疗中常见的食补充剂.
- 它在肺癌 (LC) 预防或治疗中的确切作用尚不清楚.
- 了解叶酸代谢对于癌症管理至关重要.
研究的目的:
- 调查各种叶酸形式与肺癌发病率之间的关联.
- 分析叶酸和LC风险之间的剂量反应关系.
- 评估叶酸在肺癌治疗中的潜在作用.
主要方法:
- 2007-2018年国家健康和营养检查调查 (NHANES) 的横截面分析.
- 倾向性得分匹配 (PSM) 来控制混变量.
- 限制立方线 (RCS) 用于评估叶酸水平和LC之间的非线性关系.
主要成果:
- 总叶酸,食叶酸,5-甲基四叶酸 (5-甲基THF) 和5,10-甲基叶酸 (5,10-甲基THF) 与LC风险之间发现了显著的关联.
- 在5,10-甲THF与患上LC的几率之间观察到非线性关联.
- 叶酸,全叶酸,5,10-甲THF和红细胞 (RBC) 叶酸水平与特定范围内的LC风险存在相关性.
结论:
- 肺癌的发展与总叶酸,食叶酸,5-甲基THF和5,10-甲基THF的水平有关.
- 叶酸,总叶酸,5,10-甲THF和红细胞叶酸的某些范围与LC风险有积极的相关性.
- 这些发现突显了叶酸代谢和肺癌之间的复杂关系.
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