接受CAR T治疗的淋巴瘤患者的低磁血与免疫功能障碍和生存率降低相关
Jennifer J Gile1, Patrizia Mondello1, Zixing Wang2
1Division of Hematology, Mayo Clinic, 200 SW First Street, Rochester, MN, 55905, USA.
Experimental hematology & oncology
|April 30, 2025
概括
在CAR-T治疗前血清的低水平 (低血症) 预测大B细胞淋巴瘤 (LBCL) 患者的结果会更差. 这表明水平是接受CAR-T治疗的LBCL患者的潜在预后因素.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 低磁血症与接受干细胞移植的大B细胞淋巴瘤 (LBCL) 患者的较差结果有关.
- 低水平与T细胞和髓状细胞功能障碍有关.
研究的目的:
- 为了研究血清 (Mg) 水平是否可以预测接受仿真抗原受体T细胞 (CAR-T) 治疗的LBCL患者的临床结果.
主要方法:
- 从ZUMA-1试验和梅奥诊所中分析了使用axicabtagene ciloleucel (axi-cel) 治疗的LBCL患者.
- 血清样本分析,细胞因子分析和单细胞RNA测序 (scRNAseq) 的外周血液单核细胞.
- 包括卡普兰-梅尔生存曲线和威尔科克森试验在内的统计分析.
主要成果:
- 在淋巴缺陷化疗前的高磁血症在ZUMA-1试验中预测了较低的无进展和整体存活率,该试验在独立队列中得到验证.
- 低磁血与炎症标志物 (费里丁,IL-6,IL1Ra,IL-8,MIP1a) 的升高相关.
- 在低磁性病患者中,scRNAseq揭示了改变的免疫相互作用和免疫抑制的转录组.
结论:
- 在CAR-T输液下,低热血症与不良的炎症特征,以及在接受轴细胞治疗的LBCL患者的反应和存活率的降低有关.
- 血清水平对接受CAR-T治疗的LBCL患者来说是一个潜在的可操作的预后因素.
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